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Antiulcerogenic activity of some sesquiterpene lactones isolated from Artemisia annua.
Authors: Foglio MA, Dias PC, Antonio MA, Possenti A, Rodrigues RA, da Silva EF, Rehder VL, de Carvalho JE.
Source: Planta Med. 2002 Jun;68(6):515-8
Centro Pluridisciplinar de Pesquisas Quimicas, Biologicas e Agricolas da Universidade Estadual de Campinas (CPQBA/UNICAMP), Campinas, SP, Brazil. foglioma@cpqba.unicamp.br
Artemisinin 1, dihydro-epideoxyarteannuin B 2 and deoxyartemisinin 3 were isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L. These compounds were tested on ethanol and indomethacin-induced ulcer models. Compound 1 did not afford cytoprotection under the experimental models tested. Only compounds 2 and 3 decreased the ulcerative lesion index produced by ethanol and indomethacin in rats. These compounds did not demonstrate antiulcerogenic activity when tested on the ethanol-induced ulcer model, with previous administration of indomethacin, suggesting that the antiulcerogenic activity is a consequence of prostaglandin synthesis increase.