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Effect of Padma 28 on Experimental Hyperlipidaemia and Atherosclerosis Induced by High-Fat Diet in Rabbits.
Authors: Wojcicki J, Samochowiec L, Ceglecka M, Juzyszyn A, Tustanowski S, Kadlubowska D, Juzwiak S.
Source: Phytotherapy Research, 1988, 2:3 119-123
New Zealand rabbits were divided into three equal groups: (1) controls, (2) animals receiving high-fat diet (HFD) containing cholesterol and coconut oil, and (3) HFD + Padma 28. A pronounced reductions in lipid metabolism disturbances and in severity of plaque formation occurred after Padma 28 had been administered. Lipid content in serum, liver homogenate and liver microsomes was depressed. An increase in the microsomal phosphatidycholine content was observed. The cytochrome P-450 content in liver microsomes was significantly elevated, and the concentration of malondialdehyde in the blood serum of rabbits was decreased whilst insulin levels were normalized and testosterone content was increased. Atherosclerotic plaque intensity at 12 weeks measured planimetrically averaged 67.3% in HFD-fed animals but only 15.5% in Padma 28-treated rabbits. These findings suggest that Padma 28, in addition to lowering serum lipid level in rabbits on an experimental diet, also affects metabolic processes in the liver and may modify lipid deposition in major arteries.