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Padma 28, a Botanical Compound, Decreases The Oxidative Burst Reaction of Monocytes and Improves Fibrinolysis in Patients with Stable Intermittent Claudication.
Authors: Winther K, Kharazmi A, Himmelstrup H, Drabaek H, Mehlsen J
Source: Fibrinolysis 1994;8(Suppl 2):47-49
Thirty-six patients with a median age of sixty-seven years and a median duration of stable intermittent claudication of five years were randomized to either active treatment with Padma 28 or placebo for four months. The group randomized to active therapy received twice daily two tablets, each tablet containing 340 mg of a dried herbal mixture composed according to an ancient lamaistic preparation. The group randomized to placebo received inactive tablets of indistinguishable taste, colour and size.
Platelet aggregation in vitro by ADP or collagen was not significantly changed by Padma 28, but three statistically significant findings during active drug treatment were: the “oxidative burst” of monocytes, as measured by chemiluminescence, decreased from 75.6 mVolt to 53.5 mVolt; euglobulin clot lysis time was shortened by approximately 40%, signifying a sharp increase in fibrinolytic activity, and PAI-1 activity decreased from 14.6 to 10.1 IU/ml (p<0.05). Patients on placebo showed no significant changes in any of these parameters. The possible relevance of these biochemical changes to the clinical benefit obtained from Padma 28 therapy is discussed.