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Research Library

The following scientific abstracts have been reviewed by the Dr. Eliaz staff for relevance to the ingredient Black cohosh root. Click on any of the following abstract titles to see the details of the abstract.

Title: Efficacy and tolerability of the Black cohosh (Actaea racemosa) ethanolic extract BNO 1055 on climacteric complaints: A double-blind, placebo- and conjugated estrogens-controlled study.
Authors: Wuttke W, Raus K, Gorkow C.
Journal: Maturitas. 2006 Aug 21;

Title: Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial.
Authors: Frei-Kleiner S, Schaffner W, Rahlfs VW, Bodmer Ch, Birkhauser M.
Journal: Maturitas. 2005 Aug 16;51(4):397-404. Epub 2004 Dec 10.

Title: Black cohosh: just another phytoestrogen?
Authors: Viereck V, Emons G, Wuttke W.
Journal: Trends Endocrinol Metab. 2005 Jul;16(5):214-21.

Title: Apoptosis of human prostate androgen-dependent and -independent carcinoma cells induced by an isopropanolic extract of black cohosh involves degradation of cytokeratin (CK) 18.
Authors: Hostanska K, Nisslein T, Freudenstein J, Reichling J, Saller R.
Journal: Anticancer Res. 2005 Jan-Feb;25(1A):139-47.

Title: Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial
Authors: S. Frei-Kleinera, W. Schaffnera, V.W. Rahlfsb, Ch. Bodmerc and M. Birkhäuser
Journal: Received 13 July 2004; revised 20 October 2004; accepted 21 October 2004. Available online 10 December 2004.

Title: Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells.
Authors: Hostanska K, Nisslein T, Freudenstein J, Reichling J, Saller R.
Journal: Biol Pharm Bull. 2004 Dec;27(12):1970-5.

Title: Nonestrogen treatment modalities for vasomotor symptoms associated with menopause.
Authors: Fugate SE, Church CO.
Journal: Ann Pharmacother. 2004 Sep;38(9):1482-99

Title: Concomitant administration of an isopropanolic extract of black cohosh and tamoxifen in the in vivo tumor model of implanted RUCA-I rat endometrial adenocarcinoma cells.
Authors: Nisslein T, Freudenstein J.
Journal: Toxicol Lett. 2004 May 2;150(3):271-5.

Title: Phytoestrogen Cimicifugoside-mediated Inhibition of Catecholamine secretion by Blocking Nicotinic Acetylcholine Receptor in Bovine Adrenal Chromaffin cell.
Authors: Woo KC, Park YS, Jun DJ, Lim JO, Baek WY, Suh BS, Kim KT.
Journal: J Pharmacol Exp Ther. 2004 Feb 2

Title: Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells.
Authors: Einbond LS, Shimizu M, Xiao D, Nuntanakorn P, Lim JT, Suzui M, Seter C, Pertel T, Kennelly EJ, Kronenberg F, Weinstein IB.
Journal: Breast Cancer Res Treat. 2004 Feb;83(3):221-31.

Title: Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society.
Authors: North American Menopause Society.
Journal: Menopause. 2004 Jan-Feb;11(1):11-33.

Title: Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth.
Authors: Lupu R, Mehmi I, Atlas E, Tsai MS, Pisha E, Oketch-Rabah HA, Nuntanakorn P, Kennelly EJ, Kronenberg F.
Journal: Int J Oncol. 2003 Nov; 23(5): 1407-12.

Title: Black Cohosh Acts as a Mixed Competitive Ligand and Partial Agonist of the Serotonin Receptor.
Authors: Burdette JE, Liu J, Chen SN, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, Van Breemen RB, Farnsworth NR, Bolton JL.
Journal: J Agric Food Chem. 2003 Sep 10;51(19):5661-5670.

Title: Is black cohosh estrogenic?
Authors: Mahady GB.
Journal: Nutr Rev. 2003 May;61(5 Pt 1):183-6.

Title: In vitro effects of the Cimicifuga racemosa extract BNO 1055
Authors: Jarry, H., Metten, M., Spengler, B., Christoffel, V. Wuttke, W.
Journal: Maturitas 2003 (44 Suppl 1) S31-8

Title: Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy.
Authors: Beck V, Unterrieder E, Krenn L, Kubelka W, Jungbauer A.
Journal: J Steroid Biochem Mol Biol 2003 Feb;84(2-3):259-68

Title: Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.
Authors: Burdette JE, Chen SN, Lu ZZ, Xu H, White BE, Fabricant DS, Liu J, Fong HH, Farnsworth NR, Constantinou AI, Van Breemen RB, Pezzuto JM, Bolton JL.
Journal: J Agric Food Chem 2002 Nov 20;50(24):7022-8

Title: Randomized, controlled trial of phytoestrogen in the prophylactic treatment of menstrual migraine.
Authors: Burke BE, Olson RD, Cusack BJ.
Journal: Biomed Pharmacother 2002 Aug;56(6):283-8

Title: Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract.
Authors: Freudenstein J, Dasenbrock C, Nisslein T.
Journal: Cancer Res 2002 Jun 15;62(12):3448-52

Title: Inhibitory effect of herbal remedies on 12-o-tetradecanoylphorbol-13-acetate-promoted Epstein--Barr virus early antigen activation.
Authors: Kapadia GJ, Azuine MA, Tokuda H, Hang E, Mukainaka T, Nishino H, Sridhar R.
Journal: Pharmacol Res 2002 Mar;45(3):213-220

Title: Influence of Cimicifuga racemosa on the proliferation of estrogen receptor-positive human breast cancer cells
Authors: Bodinet, C. Freudenstein, J.
Journal: Breast Cancer Res Treat 2001 76(1) 1-10

Title: Estrogenic Effects of Cimicifuga racemosa (Black Cohosh) in Mice and on Estrogen Receptors in MCF-7 Cells
Authors: Liu, Z. P., Yu, B., Huo, J. S., Lu, C. Q., Chen, J. S.
Journal: J Med Food 2001 4(3) 171-178

Title: Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer.
Authors: Jacobson JS, Troxel AB, Evans J, Klaus L, Vahdat L, Kinne D, Lo KM, Moore A, Rosenman PJ, Kaufman EL, Neugut AI, Grann VR.
Journal: J Clin Oncol 2001 May 15;19(10):2739-45

Title: Growth inhibition of human breast cancer cells by herbs and phytoestrogens.
Authors: Dixon-Shanies D, Shaikh N.
Journal: Oncol Rep 1999 Nov-Dec;6(6):1383-7

Title: Cimicifuga and Melbrosia lack oestrogenic effects in mice and rats.
Authors: Einer-Jensen N, Zhao J, Andersen KP, Kristoffersen K.
Journal: Maturitas 1996 Oct;25(2):149-53

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