Research Library
Synergistic effects of thearubigin and genistein on human prostate tumor cell (PC-3) growth via cell cycle arrest.
Authors: Sakamoto K
Source: Cancer Lett 2000 Apr 3;151(1):103-9
There is evidence that habitual consumption of green tea by Japanese
men is correlated with a reduction in cancers, including prostate;
soybean isoflavones are also associated with increased protection.
The present study compared the anti-proliferative effect of black tea
(Camellia sinensis) polyphenol, thearubigin (TR), alone or combined
with the isoflavone genistein, on human prostate (PC-3) carcinoma
cells. TR administered alone did not result in any alteration of cell
growth. When combined with genistein, however, TR significantly
inhibited cell growth and induced a G2/M phase cell cycle arrest in a
dose dependent manner. These findings indicate the potential use of
combined phytochemicals to provide protection against prostate
cancer.