Research Library

The following scientific abstracts have been reviewed by the Dr. Eliaz staff for relevance to the ingredient Soy isoflavones. Click on any of the following abstract titles to see the details of the abstract.

Title: Soy protein isolate increases urinary estrogens and the ratio of 2:16 alpha-hydroxyestrone in men at high risk of prostate cancer.
Authors: Hamilton-Reeves JM, Rebello SA, Thomas W, Slaton JW, Kurzer MS. Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA
Journal: J Nutr. 2007 Oct;137(10):2258-63.

Title: Influence of inulin on plasma isoflavone concentrations in healthy postmenopausal women.
Authors: Piazza C, Privitera MG, Melilli B, Incognito T, Marano MR, Leggio GM, Roxas MA, Drago F. Pharmacokinetic Unit, Unifarm Research Center, University of Catania, Catania, Italy.
Journal: Am J Clin Nutr. 2007 Sep;86(3):775-80

Title: Dietary Isoflavones May Protect against Prostate Cancer in Japanese Men.
Authors: Nagata Y, Sonoda T, Mori M, Miyanaga N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Akaza H.
Journal: J Nutr. 2007 Aug;137(8):1974-1979.

Title: Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial.
Authors: Marini H, Minutoli L, Polito F, Bitto A, Altavilla D, Atteritano M, Gaudio A, Mazzaferro S, Frisina A, Frisina N, Lubrano C, Bonaiuto M, D'Anna R, Cannata ML, Corrado F, Adamo EB, Wilson S, Squadrito F.
Journal: Ann Intern Med. 2007 Jun 19;146(12):839-47.

Title: The association between soy nut consumption and decreased menopausal symptoms.
Authors: Welty FK, Lee KS, Lew NS, Nasca M, Zhou JR.
Journal: J Womens Health (Larchmt). 2007 Apr;16(3):361-9.

Title: Soy Isoflavones Exert Differential Effects on Androgen Responsive Genes in LNCaP Human Prostate Cancer Cells.
Authors: Rice L, Handayani R, Cui Y, Medrano T, Samedi V, Baker H, Szabo NJ, Rosser CJ, Goodison S, Shiverick KT.
Journal: J Nutr. 2007 Apr;137(4):964-972.

Title: Soy product and isoflavone consumption in relation to prostate cancer in Japanese men.
Authors: Kurahashi N, Iwasaki M, Sasazuki S, Otani T, Inoue M, Tsugane S; Japan Public Health Center-Based Prospective Study Group.
Journal: Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):538-45. Epub 2007 Mar 2.

Title: Molecular effects of the isoflavonoid genistein in prostate cancer.
Authors: Bektic J, Guggenberger R, Eder IE, Pelzer AE, Berger AP, Bartsch G, Klocker H.
Journal: Clin Prostate Cancer. 2005 Sep;4(2):124-9.

Title: Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model.
Authors: Vantyghem SA, Wilson SM, Postenka CO, Al-Katib W, Tuck AB, Chambers AF.
Journal: Cancer Res. 2005 Apr 15;65(8):3396-403.

Title: Prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro.
Authors: Hedlund TE, Bokhoven A, Johannes WU, Nordeen SK, Ogden LG.
Journal: Prostate. 2006 Apr 1;66(5):557-66.

Title: Dietary phytoestrogens improve stroke outcome after transient focal cerebral ischemia in rats.
Authors: Burguete MC, Torregrosa G, Perez-Asensio FJ, Castello-Ruiz M, Salom JB, Gil JV, Alborch E.
Journal: Eur J Neurosci. 2006 Feb;23(3):703-710.

Title: Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast.
Authors: Wood CE, Register TC, Franke AA, Anthony MS, Cline JM.
Journal: Cancer Res. 2006 Jan 15;66(2):1241-9.

Title: Sequential, randomized trial of a low-fat, high-fiber diet and soy supplementation: effects on circulating IGF-I and its binding proteins in premenopausal women.
Authors: Gann PH, Kazer R, Chatterton R, Gapstur S, Thedford K, Helenowski I, Giovanazzi S, Van Horn L.
Journal: Int J Cancer. 2005 Aug 20;116(2):297-303.

Title: Dietary soy isoflavone-induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo.
Authors: Mahn K, Borras C, Knock GA, Taylor P, Khan IY, Sugden D, Poston L, Ward JP, Sharpe RM, Vina J, Aaronson PI, Mann GE.
Journal: FASEB J. 2005 Aug 17

Title: Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells.
Authors: Russo A, Cardile V, Lombardo L, Vanella L, Acquaviva R.
Journal: J Nutr Biochem. 2005 Aug 17

Title: Revealing anti-inflammatory mechanisms of soy isoflavones by flow: modulation of leukocyte-endothelial cell interactions.
Authors: Chacko BK, Chandler RT, Mundhekar A, Khoo N, Pruitt HM, Kucik DF, Parks DA, Kevil CG, Barnes S, Patel RP.
Journal: Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H908-15. Epub 2005 Apr 1.

Title: Possible mechanisms behind the differential effects of soy protein and casein feedings on colon cancer biomarkers in the rat.
Authors: Vis EH, Geerse GJ, Klaassens ES, van Boekel MA, Alink GM.
Journal: Nutr Cancer. 2005;51(1):37-44.

Title: Environmental influences on isoflavones and saponins in soybeans and their role in colon cancer.
Authors: Macdonald RS, Guo J, Copeland J, Browning JD Jr, Sleper D, Rottinghaus GE, Berhow MA.
Journal: J Nutr. 2005 May;135(5):1239-42.

Title: Dietary Genistein Improves Survival and Reduces Expression of Osteopontin in the Prostate of Transgenic Mice with Prostatic Adenocarcinoma (TRAMP).
Authors: Mentor-Marcel R, Lamartiniere CA, Eltoum IA, Greenberg NM, Elgavish A.
Journal: J Nutr. 2005 May;135(5):989-95.

Title: Soy, isoflavones, and prevalence of allergic rhinitis in Japanese women: the Osaka Maternal and Child Health Study.
Authors: Miyake Y, Sasaki S, Ohya Y, Miyamoto S, Matsunaga I, Yoshida T, Hirota Y, Oda H.
Journal: J Allergy Clin Immunol. 2005 Jun;115(6):1176-83.

Title: Decreased circulating levels of tumor necrosis factor-alpha (TNF-{alpha}) in postmenopausal women during consumption of soy containing isoflavones.
Authors: Huang Y, Cao S, Nagamani M, Anderson KE, Grady JJ, Lu LJ.
Journal: J Clin Endocrinol Metab. 2005 Apr 19;

Title: The soy isoflavone genistein induces a late but sustained activation of the endothelial nitric oxide-synthase system in vitro.
Authors: Rathel TR, Leikert JF, Vollmar AM, Dirsch VM.
Journal: Br J Pharmacol. 2005 Feb;144(3):394-9.

Title: Comparison between daidzein and genistein antioxidant activity in primary and cancer lymphocytes.
Authors: Foti P, Erba D, Riso P, Spadafranca A, Criscuoli F, Testolin G.
Journal: Arch Biochem Biophys. 2005 Jan 15;433(2):421-7.

Title: The novel targets for anti-angiogenesis of genistein on human cancer cells.
Authors: Su SJ, Yeh TM, Chuang WJ, Ho CL, Chang KL, Cheng HL, Liu HS, Cheng HL, Hsu PY, Chow NH.
Journal: Biochem Pharmacol. 2005 Jan 15;69(2):307-18. Epub 2004 Nov 19.

Title: Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent.
Authors: Kim H, Hall P, Smith M, Kirk M, Prasain JK, Barnes S, Grubbs C.
Journal: J Nutr. 2004 Dec;134(12 Suppl):3445S-3452S.

Title: [PSA change and morbidity of prostate cancer after dietary intervention of low-fat and high-soybean-protein diet for patients with high serum PSA level]
Authors: Tsutsumi M, Ishikawa S, Ishikawa Y.
Journal: Hinyokika Kiyo. 2004 Dec;50(12):847-51.

Title: Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways.
Authors: Valachovicova T, Slivova V, Bergman H, Shuherk J, Sliva D.
Journal: Int J Oncol. 2004 Nov;25(5):1389-95.

Title: Soy Isoflavones May Protect Against Orchidectomy-Induced Bone Loss in Aged Male Rats.
Authors: Khalil DA, Lucas EA, Smith BJ, Soung DY, Devareddy L, Juma S, Akhter MP, Recker R, Arjmandi BH.
Journal: Calcif Tissue Int. 2004 Nov 4

Title: Cellular and physiological effects of soy flavonoids.
Authors: Valachovicova T, Slivova V, Sliva D.
Journal: Mini Rev Med Chem. 2004 Oct;4(8):881-7.

Title: Modulatory effect of soy isoflavones on biochemical alterations mediated by TPA in mouse skin model.
Authors: Sharma S, Sultana S.
Journal: Food Chem Toxicol. 2004 Oct;42(10):1669-75.

Title: Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections; Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy.
Authors: Dijsselbloem N, Vanden Berghe W, De Naeyer A, Haegeman G.
Journal: Biochem Pharmacol. 2004 Sep 15;68(6):1171-85.

Title: Antioxidant activities and lipid lowering effects of isoflavone in male rabbits.
Authors: Yousef MI, Kamel KI, Esmail AM, Baghdadi HH.
Journal: Food Chem Toxicol. 2004 Sep;42(9):1497-503.

Title: Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer.
Authors: Dalais FS, Meliala A, Wattanapenpaiboon N, Frydenberg M, Suter DA, Thomson WK, Wahlqvist ML.
Journal: Urology. 2004 Sep;64(3):510-5.

Title: Genistein induces Ca2+ -mediated, calpain/caspase-12-dependent apoptosis in breast cancer cells.
Authors: Sergeev IN.
Journal: Biochem Biophys Res Commun. 2004 Aug 20;321(2):462-7.

Title: A pilot clinical study of short-term isoflavone supplements in breast cancer patients.
Authors: Sartippour MR, Rao JY, Apple S, Wu D, Henning S, Wang H, Elashoff R, Rubio R, Heber D, Brooks MN.
Journal: Nutr Cancer. 2004;49(1):59-65.

Title: Apoptosis of human primary gastric carcinoma cells induced by genistein.
Authors: Zhou HB, Chen JJ, Wang WX, Cai JT, Du Q.
Journal: World J Gastroenterol. 2004 Jun 15;10(12):1822-5.

Title: Dietary phytoestrogen intake and premenopausal breast cancer risk in a German case-control study.
Authors: Linseisen J, Piller R, Hermann S, Chang-Claude J; German Case-Control Study.
Journal: Int J Cancer. 2004 Jun 10;110(2):284-90.

Title: Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study.
Authors: Xu WH, Zheng W, Xiang YB, Ruan ZX, Cheng JR, Dai Q, Gao YT, Shu XO.
Journal: BMJ. 2004 May 29;328(7451):1285. Epub 2004 May 10.

Title: Equol is a novel anti-androgen that inhibits prostate growth and hormone feedback.
Authors: Lund TD, Munson DJ, Haldy ME, Setchell KD, Lephart ED, Handa RJ.
Journal: Biol Reprod. 2004 Apr;70(4):1188-95. Epub 2003 Dec 17.

Title: A double-blind placebo-controlled clinical trial compares the cholesterollowering effects of two different soy protein preparations in hypercholesterolemic subjects.
Authors: Hoie LH, Morgenstern EC, Gruenwald J, Graubaum HJ, Busch R, Luder W, Zunft HJ.
Journal: Eur J Nutr. 2004 Apr 5;:1-7. [Epub ahead of print]

Title: Soy Protein Favorably Affects LDL Size Independently of Isoflavones in Hypercholesterolemic Men and Women
Authors: Desroches S, Mauger JF, Ausmam LM, Lichtenstein AH, Lamarche B
Journal: J Nutr, 134:3; 574-9

Title: Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer.
Authors: deVere White RW, Hackman RM, Soares SE, Beckett LA, Li Y, Sun B
Journal: Urology, 63:2, 259-63

Title: Analgesic effects of a soy-containing diet in three murine bone cancer pain models.
Authors: Zhao C, Wacnik PW, Tall JM, Johns DC, Wilcox GL, Meyer RA, Raja SN.
Journal: J Pain. 2004 Mar;5(2):104-10.

Title: Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice.
Authors: Zhou JR, Yu L, Mai Z, Blackburn GL.
Journal: Int J Cancer. 2004 Jan 1;108(1):8-14.

Title: Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society.
Authors: North American Menopause Society.
Journal: Menopause. 2004 Jan-Feb;11(1):11-33.

Title: Genistein may prevent cadmium-induced bone loss in ovariectomized rats
Authors: Paik MK, Lee HO, Chung HS, Yang SO, Kim JH, Om AS
Journal: J Med Food, 6:4, 337-43

Title: Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of sprague-dawley rats.
Authors: Allred CD, Allred KF, Ju YH, Clausen LM, Doerge DR, Schantz SL, Korol DL, Wallig MA, Helferich WG.
Journal: Carcinogenesis. 2003 Oct 24 [Epub ahead of print].

Title: Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial.
Authors: Chen YM, Ho SC, Lam SS, Ho SS, Woo JL.
Journal: J Clin Endocrinol Metab. 2003 Oct;88(10):4740-7.

Title: Genistein reduces NF-kappa B in T lymphoma cells via a caspase-mediated cleavage of I kappa B alpha.
Authors: Baxa DM, Yoshimura FK.
Journal: Biochem Pharmacol. 2003 Sep 15;66(6):1009-18.

Title: Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein.
Authors: Kazi A, Daniel KG, Smith DM, Kumar NB, Dou QP.
Journal: Biochem Pharmacol. 2003 Sep 15;66(6):965-76.

Title: Recreational physical activity and the risk of breast cancer in postmenopausal women: the Women's Health Initiative Cohort Study.
Authors: McTiernan A, Kooperberg C, White E, Wilcox S, Coates R, Adams-Campbell LL, Woods N, Ockene J; Women's Health Initiative Cohort Study.
Journal: JAMA. 2003 Sep 10;290(10):1331-6.

Title: Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies.
Authors: Setchell KD, Lydeking-Olsen E.
Journal: Am J Clin Nutr. 2003 Sep;78(3 Suppl):593S-609S.

Title: The effect of a soy rich diet on the vaginal epithelium in postmenopause: a randomized double blind trial.
Authors: Chiechi LM, Putignano G, Guerra V, Schiavelli MP, Cisternino AM, Carriero C.
Journal: Maturitas. 2003 Aug 20;45(4):241-6.

Title: Phytoestrogen intake and endometrial cancer risk.
Authors: Horn-Ross PL, John EM, Canchola AJ, Stewart SL, Lee MM.
Journal: J Natl Cancer Inst. 2003 Aug 6;95(15):1158-64.

Title: Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells.
Authors: Wilson LC, Baek SJ, Call A, Eling TE.
Journal: Int J Cancer. 2003 Jul 20;105(6):747-753.

Title: Soy and isoflavone consumption in relation to prostate cancer risk in china.
Authors: Lee MM, Gomez SL, Chang JS, Wey M, Wang RT, Hsing AW.
Journal: Cancer Epidemiol Biomarkers Prev. 2003 Jul;12(7):665-8.

Title: Urinary equol excretion in relation to 2-hydroxyestrone and 16alpha-hydroxyestrone concentrations: an observational study of young to middle-aged women.
Authors: Atkinson C, Skor HE, Dawn Fitzgibbons E, Scholes D, Chen C, Wahala K, Schwartz SM, Lampe JW.
Journal: J Steroid Biochem Mol Biol. 2003 Jul;86(1):71-7.

Title: Indole-3-carbinol is a negative regulator of estrogen.
Authors: Auborn KJ, Fan S, Rosen EM, Goodwin L, Chandraskaren A, Williams DE, Chen D, Carter TH.
Journal: J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S

Title: Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy, as evidenced by reducing bone resorption and urinary calcium excretion.
Authors: Arjmandi BH, Khalil DA, Smith BJ, Lucas EA, Juma S, Payton ME, Wild RA.
Journal: J Clin Endocrinol Metab 2003 Mar;88(3):1048-54

Title: Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency.
Authors: Messina M, Hughes C.
Journal: J Med Food. 2003 Spring;6(1):1-11.

Title: Effect of genistein on endothelial function in postmenopausal women: a randomized, double-blind, controlled study.
Authors: Squadrito F, Altavilla D, Crisafulli A, Saitta A, Cucinotta D, Morabito N, D'Anna R, Corrado F, Ruggeri P, Frisina N, Squadrito G.
Journal: Am J Med. 2003 Apr 15;114(6):470-6.

Title: Soy product intake is inversely associated with serum homocysteine level in premenopausal Japanese women.
Authors: Nagata C, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K.
Journal: J Nutr. 2003 Mar;133(3):797-800.

Title: Comparing the pharmacokinetics of daidzein and genistein with the use of (13)C-labeled tracers in premenopausal women.
Authors: Setchell KD, Faughnan MS, Avades T, Zimmer-Nechemias L, Brown NM, Wolfe BE, Brashear WT, Desai P, Oldfield MF, Botting NP, Cassidy A.
Journal: Am J Clin Nutr 2003 Feb;77(2):411-419

Title: Genistein and daidzein downregulate prostate androgen-regulated transcript-1 (PART-1) gene expression induced by dihydrotestosterone in human prostate LNCaP cancer cells.
Authors: Yu L, Blackburn GL, Zhou JR.
Journal: J Nutr 2003 Feb;133(2):389-92

Title: Glucuronides are the main isoflavone metabolites in women.
Authors: Zhang Y, Hendrich S, Murphy PA.
Journal: J Nutr 2003 Feb;133(2):399-404

Title: Soy consumption and phytoestrogens: effect on serum prostate specific antigen when blood lipids and oxidized low-density lipoprotein are reduced in hyperlipidemic men.
Authors: Jenkins DJ, Kendall CW, D'Costa MA, Jackson CJ, Vidgen E, Singer W, Silverman JA, Koumbridis G, Honey J, Rao AV, Fleshner N, Klotz L.
Journal: J Urol 2003 Feb;169(2):507-11

Title: Dietary supplements of soya flour lower serum testosterone concentrations and improve markers of oxidative stress in men.
Authors: Gardner-Thorpe D, O'Hagen C, Young I, Lewis SJ.
Journal: Eur J Clin Nutr 2003 Jan;57(1):100-6

Title: Soy foods and soybean isoflavones and menopausal health.
Authors: Messina MJ.
Journal: Nutr Clin Care 2002 Nov-Dec;5(6):272-82

Title: Dietary supplementation with isolated soy protein reduces metastasis of mammary carcinoma cells in mice.
Authors: Yan L, Li D, Yee JA.
Journal: Clin Exp Metastasis 2002;19(6):535-40

Title: Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by fermented soy milk.
Authors: Chang WH, Liu JJ, Chen CH, Huang TS, Lu FJ.
Journal: Nutr Cancer 2002;43(2):214-26

Title: Beneficial Effects of Soy Phytoestrogen Intake in Postmenopausal Women With Type 2 Diabetes.
Authors: Jayagopal V, Albertazzi P, Kilpatrick ES, Howarth EM, Jennings PE, Hepburn DA, Atkin SL.
Journal: Diabetes Care 2002 Oct;25(10):1709-1714

Title: Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate tumors in mice by bioactive soybean components.
Authors: Zhou JR, Yu L, Zhong Y, Nassr RL, Franke AA, Gaston SM, Blackburn GL.
Journal: Prostate 2002 Oct 1;53(2):143-53

Title: Adolescent and adult soy intake and risk of breast cancer in Asian-Americans.
Authors: Wu AH, Wan P, Hankin J, Tseng CC, Yu MC, Pike MC.
Journal: Carcinogenesis 2002 Sep;23(9):1491-6

Title: Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women.
Authors: Jenkins DJ, Kendall CW, Jackson CJ, Connelly PW, Parker T, Faulkner D, Vidgen E, Cunnane SC, Leiter LA, Josse RG.
Journal: Am J Clin Nutr 2002 Aug;76(2):365-72

Title: Inhibition of estrogenic stimulation of gene expression by genistein.
Authors: Ratna WN.
Journal: Life Sci 2002 Jul 12;71(8):865-877

Title: Hot flushes and other menopausal symptoms in relation to soy product intake in Japanese women.
Authors: Nagata C, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K.
Journal: Climacteric 1999 Mar;2(1):6-12

Title: Comparative study of concentration of isoflavones and lignans in plasma and prostatic tissues of normal control and benign prostatic hyperplasia.
Authors: Hong SJ, Kim SI, Kwon SM, Lee JR, Chung BC.
Journal: Yonsei Med J 2002 Apr;43(2):236-41

Title: Genistein chemoprevention: timing and mechanisms of action in murine mammary and prostate.
Authors: Lamartiniere CA, Cotroneo MS, Fritz WA, Wang J, Mentor-Marcel R, Elgavish A.
Journal: J Nutr 2002 Mar;132(3):552S-8S

Title: Hormonal effects of soy in premenopausal women and men.
Authors: Kurzer MS.
Journal: J Nutr 2002 Mar;132(3):570S-3S

Title: The specific role of isoflavones on estrogen metabolism in premenopausal women.
Authors: Kumar NB, Cantor A, Allen K, Riccardi D, Cox CE.
Journal: Cancer 2002 Feb 15;94(4):1166-74

Title: Dietary genistein down-regulates androgen and estrogen receptor expression in the rat prostate.
Authors: Fritz WA, Wang J, Eltoum IE, Lamartiniere CA.
Journal: Mol Cell Endocrinol 2002 Jan 15;186(1):89-99

Title: Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats.
Authors: Weber KS, Setchell KD, Stocco DM, Lephart ED.
Journal: J Endocrinol 2001 Sep;170(3):591-9

Title: Soy for breast cancer survivors: a critical review of the literature.
Authors: Messina MJ, Loprinzi CL.
Journal: J Nutr 2001 Nov;131(11):3095S-108S

Title: Genistein in the diet reduces the incidence of poorly differentiated prostatic adenocarcinoma in transgenic mice (TRAMP).
Authors: Mentor-Marcel R, Lamartiniere CA, Eltoum IE, Greenberg NM, Elgavish A.
Journal: Cancer Res 2001 Sep 15;61(18):6777-82

Title: Effects of an isoflavone-free soy diet on ovarian hormones in premenopausal women.
Authors: Lu LJ, Anderson KE, Grady JJ, Nagamani M.
Journal: J Clin Endocrinol Metab 2001 Jul;86(7):3045-52

Title: Effect of a phytoestrogen food supplement on reproductive health in normal males.
Authors: Mitchell JH, Cawood E, Kinniburgh D, Provan A, Collins AR, Irvine DS.
Journal: Clin Sci (Colch) 2001 Jun;100(6):613-8

Title: Genistein blocks breast cancer cells in the G(2)M phase of the cell cycle.
Authors: Cappelletti V; Fioravanti L; Miodini P; Di Fronzo G
Journal: J Cell Biochem 2000 Dec 15;79(4):594-600

Title: Effects of genistein and synergistic action in combination with eicosapentaenoic acid on the growth of breast cancer cell lines.
Authors: Nakagawa H; Yamamoto D; Kiyozuka Y; Tsuta K Uemura Y; Hioki K; Tsutsui Y; Tsubura A
Journal: J Cancer Res Clin Oncol 2000 Aug;126(8):448-54

Title: Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.
Authors: Fukai T; Sakagami H; Toguchi M; Takayama F Iwakura I; Atsumi T; Ueha T; Nakashima H; Nomura T
Journal: Anticancer Res 2000 Jul-Aug;20(4):2525-36

Title: Soy consumption alters endogenous estrogen metabolism in postmenopausal women [In Process Citation]
Authors: Xu X; Duncan AM; Wangen KE; Kurzer MS
Journal: Cancer Epidemiol Biomarkers Prev 2000 Aug;9(8):781-6

Title: Decreased ovarian hormones during a soya diet: implications for breast cancer prevention.
Authors: Lu LJ; Anderson KE; Grady JJ; Kohen F; Nagamani M
Journal: Cancer Res 2000 Aug 1;60(15):4112-21

Title: Biological properties of genistein. A review of in vitro and in vivo data.
Authors: Polkowski K; Mazurek AP
Journal: Acta Pol Pharm 2000 Mar-Apr;57(2):135-55

Title: Medicinal foodstuffs. XVIII. Phytoestrogens from the aerial part of Petroselinum crispum MIll. (Parsley) and structures of 6"-acetylapiin and a new monoterpene glycoside, petroside [In Process Citation]
Authors: Yoshikawa M; Uemura T; Shimoda H; Kishi A Kawahara Y; Matsuda H
Journal: Chem Pharm Bull (Tokyo) 2000 Jul;48(7):1039-44

Title: Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans.
Authors: Wiseman H; O'Reilly JD; Adlercreutz H; Mallet AI Bowey EA; Rowland IR; Sanders TA
Journal: Am J Clin Nutr 2000 Aug;72(2):395-400

Title: p21CIP1 is dispensable for the G2 arrest caused by genistein in human melanoma cells.
Authors: Casagrande F; Darbon JM
Journal: Exp Cell Res 2000 Jul 10;258(1):101-8

Title: Prevention of induced prostate-related cancer by soy protein isolate/isoflavone-supplemented diet in Lobund-Wistar rats [In Process Citation]
Authors: Pollard M; Wolter W; Sun L
Journal: In Vivo 2000 May-Jun;14(3):389-92

Title: Premenopausal equol excretors show plasma hormone profiles associated with lowered risk of breast cancer [In Process Citation]
Authors: Duncan AM; Merz-Demlow BE; Xu X; Phipps WR Kurzer MS
Journal: Cancer Epidemiol Biomarkers Prev 2000 Jun;9(6):581-6

Title: Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice.
Authors: Santell RC; Kieu N; Helferich WG
Journal: J Nutr 2000 Jul;130(7):1665-9

Title: Protection against breast cancer with genistein: a component of soy.
Authors: Lamartiniere CA
Journal: Am J Clin Nutr 2000 Jun;71(6 Suppl):1705S-7S; discussion 1708S-9S

Title: Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells.
Authors: Genistein, a natural isoflavone found in soybeans, exerts a number of biological actions suggesting that it may have a role in cancer prevention. We have previously shown that it potently inhibits OCM-1 melanoma cell proliferation by
Journal: J Biol Chem 2000 May 19;275(20):15363-9

Title: Inhibition of UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A431 cells by genistein.
Authors: Chan WH; Yu JS
Journal: J Cell Biochem 2000 Apr;78(1):73-84

Title: Urinary pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein.
Authors: Shelnutt SR; Cimino CO; Wiggins PA; Badger TM
Journal: Cancer Epidemiol Biomarkers Prev 2000 Apr;9(4):413-9

Title: Inhibitory effects of Bifidobacterium-fermented soy milk on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinogenesis, with a partial contribution of its component isoflavones.
Authors: Ohta T; Nakatsugi S; Watanabe K; Kawamori T Ishikawa F; Morotomi M; Sugie S; Toda T; Sugimura T Wakabayashi K
Journal: Carcinogenesis 2000 May;21(5):937-41

Title: Effect of intact and isoflavone-depleted soy protein on NMU-induced rat mammary tumorigenesis.
Authors: Cohen LA; Zhao Z; Pittman B; Scimeca JA
Journal: Carcinogenesis 2000 May;21(5):929-35

Title: Effect of soy protein foods on low-density lipoprotein oxidation and ex vivo sex hormone receptor activity--a controlled crossover trial.
Authors: Jenkins DJ; Kendall CW; Garsetti M Rosenberg-Zand RS; Jackson CJ; Agarwal S; Rao AV; Diamandis EP; Parker T Faulkner D; Vuksan V; Vidgen E
Journal: Metabolism 2000 Apr;49(4):537-43

Title: Anti-tumor-promoting effects of isoflavonoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Authors: Ito C; Itoigawa M; Tan HT; Tokuda H; Yang Mou X Mukainaka T; Ishikawa T; Nishino H; Furukawa H
Journal: Cancer Lett 2000 May 1;152(2):187-92

Title: Synergistic effects of thearubigin and genistein on human prostate tumor cell (PC-3) growth via cell cycle arrest.
Authors: Sakamoto K
Journal: Cancer Lett 2000 Apr 3;151(1):103-9

Title: Anabolic effect of genistein in osteoblastic MC3T3-E1 cells.
Authors: Sugimoto E; Yamaguchi M
Journal: Int J Mol Med 2000 May;5(5):515-20

Title: p53-independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells.
Authors: Choi YH; Lee WH; Park KY; Zhang L
Journal: Jpn J Cancer Res 2000 Feb;91(2):164-73

Title: Soyfoods, soybean isoflavones, and bone health: a brief overview.
Authors: Messina M; Messina V
Journal: J Ren Nutr 2000 Apr;10(2):63-8

Title: Increased urinary excretion of 2-hydroxyestrone but not 16alpha-hydroxyestrone in premenopausal women during a soya diet containing isoflavones.
Authors: Lu LJ; Cree M; Josyula S; Nagamani M; Grady JJ Anderson KE
Journal: Cancer Res 2000 Mar 1;60(5):1299-305

Title: Effect of isoflavones on mammary gland and endometrium of postmenopausal macaques (Macaca fascicularis)
Authors: Foth D; Cline JM; Romer T
Journal: Zentralbl Gynakol 2000;122(2):96-102

Title: Genistein inhibits NF-kappa B activation in prostate cancer cells.
Authors: Davis JN; Kucuk O; Sarkar FH
Journal: Nutr Cancer 1999;35(2):167-74

Title: Decreased growth of human prostate LNCaP tumors in SCID mice fed a low-fat, soy protein diet with isoflavones.
Authors: Aronson WJ; Tymchuk CN; Elashoff RM; McBride WH McLean C; Wang H; Heber D
Journal: Nutr Cancer 1999;35(2):130-6

Title: Health potential of soy isoflavones for menopausal women.
Authors: Anderson JJ; Anthony MS; Cline JM; Washburn SA Garner SC
Journal: Public Health Nutr 1999 Dec;2(4):489-504

Title: A nonisotopic enzyme-based immunoassay for assessing human exposure to genistein.
Authors: Kohen F; Gayer B; Amir-Zaltsman Y; Ben-Hur H Thomas E; Lu LJ
Journal: Nutr Cancer 1999;35(1):96-103

Title: Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.
Authors: Shertzer HG; Puga A; Chang C; Smith P; Nebert DW Setchell KD; Dalton TP
Journal: Chem Biol Interact 1999 Nov 15;123(1):31-49

Title: Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast.
Authors: Hargreaves DF; Potten CS; Harding C; Shaw LE Morton MS; Roberts SA; Howell A; Bundred NJ
Journal: J Clin Endocrinol Metab 1999 Nov;84(11):4017-24

Title: Phytoestrogens in health and disease.
Authors: Davis SR; Dalais FS; Simpson ER; Murkies AL
Journal: Recent Prog Horm Res 1999;54:185-210; discussion 210-1

Title: Soy induces phase II enzymes but does not inhibit dimethylbenz[a]anthracene-induced carcinogenesis in female rats.
Authors: Appelt LC; Reicks MM
Journal: J Nutr 1999 Oct;129(10):1820-6

Title: Legumes and soybeans: overview of their nutritional profiles and health effects.
Authors: Messina MJ
Journal: Am J Clin Nutr 1999 Sep;70(3 Suppl):439S-450S

Title: Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines.
Authors: Kuntz S; Wenzel U; Daniel H
Journal: Eur J Nutr 1999 Jun;38(3):133-42

Title: Soyfoods, isoflavones and risk of colonic cancer: a review of the in vitro and in vivo data.
Authors: Messina M; Bennink M
Journal: Baillieres Clin Endocrinol Metab 1998 Dec;12(4):707-28

Title: Reproductive actions of phytoestrogens.
Authors: Whitten PL; Naftolin F
Journal: Baillieres Clin Endocrinol Metab 1998 Dec;12(4):667-90

Title: Phytoestrogens and diseases of the prostate gland.
Authors: Griffiths K; Denis L; Turkes A; Morton MS
Journal: Baillieres Clin Endocrinol Metab 1998 Dec;12(4):625-47

Title: Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice.
Authors: Constantinou AI; Krygier AE; Mehta RR
Journal: Am J Clin Nutr 1998 Dec;68(6 Suppl):1426S-1430S

Title: Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways.
Authors: Kim H; Peterson TG; Barnes S
Journal: Am J Clin Nutr 1998 Dec;68(6 Suppl):1418S-1425S

Title: Effects of mammalian and plant estrogens on mammary glands and uteri of macaques.
Authors: Foth D; Cline JM
Journal: Am J Clin Nutr 1998 Dec;68(6 Suppl):1413S-1417S

Title: Genistein-induced G2-M arrest, p21WAF1 upregulation, and apoptosis in a non-small-cell lung cancer cell line.
Authors: Lian F; Bhuiyan M; Li YW; Wall N; Kraut M; Sarkar FH
Journal: Nutr Cancer 1998;31(3):184-91

Title: HPLC analysis of isoflavonoids and other phenolic agents from foods and from human fluids.
Authors: Franke AA; Custer LJ; Wang W; Shi CY
Journal: Proc Soc Exp Biol Med 1998 Mar;217(3):263-73

Title: Genistein blocks breast cancer cells in the G(2)M phase of the cell cycle.
Authors: Cappelletti V; Fioravanti L; Miodini P; Di Fronzo G
Journal: J Cell Biochem 2000 Dec 15;79(4):594-600

Title: Effect of isoflavones genistein and daidzein in the inhibition of lung metastasis in mice induced by B16F-10 melanoma cells.
Authors: Menon LG; Kuttan R; Nair MG; Chang YC; Kuttan G
Journal: Nutr Cancer 1998;30(1):74-7

Title: Inhibition of aberrant proliferation and induction of apoptosis in pre-neoplastic human mammary epithelial cells by natural phytochemicals.
Authors: Katdare M; Osborne MP; Telang NT
Journal: Oncol Rep 1998 Mar-Apr;5(2):311-5

Title: Chemoprevention of N-nitroso-N-methylurea-induced rat mammary carcinogenesis by soy foods or biochanin A.
Authors: Gotoh T; Yamada K; Yin H; Ito A; Kataoka T; Dohi K
Journal: Jpn J Cancer Res 1998 Feb;89(2):137-42

Title: Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells.
Authors: Choi YH; Zhang L; Lee WH; Park KY
Journal: Int J Oncol 1998 Aug;13(2):391-6

Title: Dietary soy intake and urinary isoflavone excretion among women from a multiethnic population.
Authors: Maskarinec G; Singh S; Meng L; Franke AA
Journal: Cancer Epidemiol Biomarkers Prev 1998 Jul;7(7):613-9

Title: Differential effect of genistein on transforming growth factor beta 1 expression in normal and malignant mammary epithelial cells.
Authors: Sathyamoorthy N; Gilsdorf JS; Wang TT
Journal: Anticancer Res 1998 Jul-Aug;18(4A):2449-53

Title: In vivo toxicity and pharmacokinetic features of B43(Anti-CD19)-Genistein immunoconjugate.
Authors: Ek O; Yanishevski Y; Zeren T; Waurzyniak B Gunther R; Chelstrom L; Chandan-Langlie M; Schneider E; Myers DE Evans W; Uckun FM
Journal: Leuk Lymphoma 1998 Jul;30(3-4):389-94

Title: Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice.
Authors: Wei H; Bowen R; Zhang X; Lebwohl M
Journal: Carcinogenesis 1998 Aug;19(8):1509-14

Title: The effect of soy isoflavones on the development of intestinal neoplasia in ApcMin mouse.
Authors: Sorensen IK; Kristiansen E; Mortensen A Nicolaisen GM; Wijnands JA; van Kranen HJ; van Kreijl CF
Journal: Cancer Lett 1998 Aug 14;130(1-2):217-25

Title: Inhibition of neoplastic transformation and bioavailability of dietary flavonoid agents.
Authors: Franke AA; Cooney RV; Custer LJ; Mordan LJ; Tanaka Y
Journal: Adv Exp Med Biol 1998;439:237-48

Title: Genistein blocks breast cancer cells in the G(2)M phase of the cell cycle.
Authors: Cappelletti V; Fioravanti L; Miodini P; Di Fronzo G
Journal: J Cell Biochem 2000 Dec 15;79(4):594-600

Title: Isoflavones in human breast milk and other biological fluids.
Authors: Franke AA; Custer LJ; Tanaka Y
Journal: Am J Clin Nutr 1998 Dec;68(6 Suppl):1466S-1473S

Title: Metabolism of the isoflavones genistein and biochanin A in human breast cancer cell lines.
Authors: Peterson TG; Ji GP; Kirk M; Coward L; Falany CN Barnes S
Journal: Am J Clin Nutr 1998 Dec;68(6 Suppl):1505S-1511S

Title: Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women.
Authors: Xu X; Duncan AM; Merz BE; Kurzer MS
Journal: Cancer Epidemiol Biomarkers Prev 1998 Dec;7(12):1101-8

Title: Soy isoflavones exert modest hormonal effects in premenopausal women.
Authors: Duncan AM; Merz BE; Xu X; Nagel TC; Phipps WR Kurzer MS
Journal: J Clin Endocrinol Metab 1999 Jan;84(1):192-7

Title: Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells.
Authors: Constantinou AI; Kamath N; Murley JS
Journal: Eur J Cancer 1998 Nov;34(12):1927-34

Title: Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations.
Authors: Zhang Y; Song TT; Cunnick JE; Murphy PA; Hendrich S
Journal: J Nutr 1999 Feb;129(2):399-405

Title: Genistein-induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells.
Authors: Davis JN; Singh B; Bhuiyan M; Sarkar FH
Journal: Nutr Cancer 1998;32(3):123-31

Title: The isoflavone genistein inhibits internalization of enteric bacteria by cultured Caco-2 and HT-29 enterocytes.
Authors: Wells CL; Jechorek RP; Kinneberg KM; Debol SM Erlandsen SL
Journal: J Nutr 1999 Mar;129(3):634-40

Title: Soybean isoflavones reduce experimental metastasis in mice.
Authors: Li D; Yee JA; McGuire MH; Murphy PA; Yan L
Journal: J Nutr 1999 May;129(5):1075-8

Title: Certain aspects of molecular endocrinology that relate to the influence of dietary factors on the pathogenesis of prostate cancer.
Authors: Griffiths K; Morton MS; Denis L
Journal: Eur Urol 1999;35(5-6):443-55

Title: The bioavailability of non-nutrient plant factors: dietary flavonoids and phyto-oestrogens.
Authors: Wiseman H
Journal: Proc Nutr Soc 1999 Feb;58(1):139-46

Title: Effects of soy or rye supplementation of high-fat diets on colon tumour development in azoxymethane-treated rats.
Authors: Davies MJ; Bowey EA; Adlercreutz H; Rowland IR Rumsby PC
Journal: Carcinogenesis 1999 Jun;20(6):927-31

Title: Effects of a soybean isoflavone mixture on carcinogenesis in prostate and seminal vesicles of F344 rats.
Authors: : Onozawa M; Kawamori T; Baba M; Fukuda K; Toda T Sato H; Ohtani M; Akaza H; Sugimura T; Wakabayashi K
Journal: Jpn J Cancer Res 1999 Apr;90(4):393-8

Title: Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum.
Authors: Lee JM, Kwon H, Jeong H, Lee JW, Lee SY, Baek SJ, Surh YJ.
Journal: Phytother Res 2001 May;15(3):245-9

Dr. Isaac Eliaz

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